RecruitingNot ApplicableNCT05975671

Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis

Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis (REVAMP-Sepsis)

Sponsor

Children's Hospital of Philadelphia

Enrollment

52,500 participants

Start Date

Aug 21, 2023

Study Type

INTERVENTIONAL

Conditions

Sepsis Septic Shock Sepsis Mrsa Sepsis Bacteremia Antimicrobial - Induced Nephropathy Sepsis, Severe Septic Syndrome

Summary

The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU). There are two groups of subjects in this study: PICU clinicians/sepsis stakeholders and patients admitted to one of the participating PICUs during the study period. The intervention will at a minimum include: * Implementation of a clinical guideline indicating when vancomycin should and should not be used * Unit-level feedback on overall vancomycin use within and across centers * Clinician education.

Eligibility

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a behavioral approach called Multifaceted de-implementation strategy to reduce vancomycin overuse for people with antimicrobial - induced nephropathy, sepsis, and other related conditions. The study is currently recruiting participants at 4 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALMultifaceted de-implementation strategy to reduce vancomycin overuse

* Clinical guidelines and group-level feedback on vancomycin use will be provided to clinicians/sepsis stakeholders at each site. * The semi-structured interviews will be performed by a trained member of the research team, under the supervision of a medical sociologist who is one of the co-investigators. A semi-structured interview guide will be used during the interviews. Interviews will be recorded and transcribed, then uploaded to a qualitative analysis software for management and coding. Names will not be recorded, and pseudonyms will be used in notes, communications about the study, and any presentations. Verbal consent will be obtained before conducting and recording the interviews. * The surveys will be performed using REDCap survey software, and participation will be voluntary. No identifiers will be collected.