RecruitingNCT05990348

Estimation of the Diaphragm Electrical Activity and Intercostal Thickening Fraction During Different Pattern of Mechanical Ventilation: PSV Versus NAVA


Sponsor

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Enrollment

20 participants

Start Date

Jul 1, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

the introduction of new MV modalities has shown promising results in reducing the incidence of weaning failure, mainly due to a more physiologic approach which allows respiratory muscle preservation. Among them, the Neurally Adjust Ventilatory Assist (NAVA) seemed to be associated with lower incidence of weaning failure and subsequent duration of mechanical ventilation, compared to standard modalities like the Pressure Support Ventilation (PSV) . Moreover, NAVA allows the evaluation of the diaphragm electrical activity (EAdi), an index of diaphragmatic neural respiratory drive. However, no study has compared TFic values during PSV and NAVA modalities in patients with difficult weaning from MV admitted in ICU.


Eligibility

Min Age: 18 Years

Inclusion Criteria2

  • patients who have failed at least one weaning attempt
  • mechanical ventilation for at least 24 hours

Exclusion Criteria4

  • Pregnancy
  • Obesity (Body Mass Index > 35 kg/m2)
  • Contraindication to the insert of a nasogastric tube
  • Neuromuscular diseases

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Interventions

OTHERdifficult weaning patients

intercostal thickening fraction values during PSV and NAVA modalities in patients with difficult weaning from MV admitted in ICU.


Locations(1)

Giorgia Spinazzola

Rome, Italy

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NCT05990348


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