Estimation of the Diaphragm Electrical Activity and Intercostal Thickening Fraction During Different Pattern of Mechanical Ventilation: PSV Versus NAVA
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
20 participants
Jul 1, 2022
OBSERVATIONAL
Conditions
Summary
the introduction of new MV modalities has shown promising results in reducing the incidence of weaning failure, mainly due to a more physiologic approach which allows respiratory muscle preservation. Among them, the Neurally Adjust Ventilatory Assist (NAVA) seemed to be associated with lower incidence of weaning failure and subsequent duration of mechanical ventilation, compared to standard modalities like the Pressure Support Ventilation (PSV) . Moreover, NAVA allows the evaluation of the diaphragm electrical activity (EAdi), an index of diaphragmatic neural respiratory drive. However, no study has compared TFic values during PSV and NAVA modalities in patients with difficult weaning from MV admitted in ICU.
Eligibility
Inclusion Criteria2
- patients who have failed at least one weaning attempt
- mechanical ventilation for at least 24 hours
Exclusion Criteria4
- Pregnancy
- Obesity (Body Mass Index > 35 kg/m2)
- Contraindication to the insert of a nasogastric tube
- Neuromuscular diseases
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Interventions
intercostal thickening fraction values during PSV and NAVA modalities in patients with difficult weaning from MV admitted in ICU.
Locations(1)
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NCT05990348