Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration
University of California, San Francisco
48 participants
Jul 1, 2025
INTERVENTIONAL
Conditions
Summary
This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco. The project aims to describe the pharmacokinetics and pharmacodynamics of marijuana-tobacco co-administration by delivering THC and nicotine in various combinations. This foundational study will establish a research program focused on elucidating the public health consequences of marijuana-tobacco co-use.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Participants will vape marijuana in varying doses from the PAX device
Participants will vape Regular and Very Low Nicotine content cigarettes from the PAX device
In all arms, participants will be using the PAX Loose Leave Vaporizer.
Participants will vape placebo marijuana from the PAX device
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05999383