Attentional Mechanisms in SCD
Attentional Mechanisms of Cognitive Compensation in Subjective Cognitive Decline
Vanderbilt University Medical Center
80 participants
Mar 27, 2025
INTERVENTIONAL
Conditions
Summary
This study will use an anticholinergic pharmacological probe to examine attention network function in SCD using EEG. The overall hypothesis is that in older adults with SCD, normal cognitive performance is maintained by compensatory attention network activity, supported by enhanced cholinergic function. The investigators anticipate that SCD will be associated with greater compensatory attention network activity and that disrupting this compensatory process through anticholinergic challenge will result in a greater negative effect on attentional performance (Attention Network Test, ANT) and attention network functioning (EEG) in older adults with greater subjective cognitive concern.
Eligibility
Inclusion Criteria3
- age ≥ 55
- Montreal Cognitive Assessment (MoCA) > 25 AND Global Deterioration Scale (GDS) rating < 3
- Non-smokers
Exclusion Criteria2
- medical contraindications to the drug challenge
- primary neurological disorder (such as stroke, epilepsy, etc.)
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Interventions
Mecamylamine 20 mg oral pill administered once
Matching placebo oral pill administered once
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06002477