RecruitingNot ApplicableNCT06012227

Assessment Metabolic Flexibility in Middle-aged Individuals: The Nutritional Impact of Cheese Consumption

Assessment Metabolic Flexibility by Indirect Calorimetry and Circulating Metabolic Parameters in Middle-aged Individuals: The Nutritional Impact of Cheese From Extensive and Intensive Farming.

Sponsor

University of Cagliari

Enrollment

105 participants

Start Date

Jan 20, 2022

Study Type

INTERVENTIONAL

Conditions

Nutrition Metabolism

Summary

The aim of the study will be to evaluate the impact of consumption of meat and dairy products from extensive or intensive farming on apparently healthy individuals aged between 45 and 65 years, a stage of life associated with reduced metabolic flexibility and changes in lipid metabolism. The study will analyze: 1. The transcription factor PPAR-α determined by the gene expression of PPAR-α in white blood cells, variations in circulating fatty acid metabolism, and the endocannabinoid system determined by circulating analysis of N-acylethanolamine (NAE), and 2-monoacylglycerols (2-MG); 2. Metabolic flexibility, determined by indirect calorimetry in fasting condition during an incremental exercise; 3. Body composition, determined by bioimpedance analysis, waist circumference, and waist-to-hip ratio.

Eligibility

Min Age: 45 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study looks at how eating cheese from grass-fed (extensive) versus factory-farmed (intensive) cows affects metabolism in middle-aged adults between 45 and 65 years old. Researchers are testing whether the type of farming changes how the body processes fats, using blood tests, body composition measurements, and an exercise breathing test. You may be eligible if you are 45–65 years old, have a BMI under 27, and are in generally good health without metabolic diseases or food intolerances. Participation involves eating 350 grams of pecorino cheese per week for 4 weeks, taking a break, then switching to the other type of cheese, along with blood draws and physical measurements. This summary was prepared to help patients understand the study in plain language.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTkent'erbas cheese study

Nutritional intervention with "kent'erbas" pecorino from extensive farming with crossover and "industrial" pecorino from intensive farming

Locations(1)

University of Cagliari

Monserrato, Cagliari, Italy

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NCT06012227

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Assessment Metabolic Flexibility in Middle-aged Individuals: The Nutritional Impact of Cheese Consumption

Conditions

Summary

Eligibility

Plain Language Summary

Interventions

Locations(1)

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