MR-Adaptive Radiation Therapy for Anal Cancer With EScalated-Treatment in a Risk-Optimized Approach

This study uses an advanced, adaptive form of radiation therapy (guided by MRI scans) for anal cancer, adjusting the radiation plan in real time to the patient's anatomy. The goal is to deliver precise treatment with fewer side effects. **You may be eligible if...** - You have been diagnosed with anal squamous cell carcinoma confirmed by biopsy - Your cancer has not spread to distant organs (stages T1–T4, N0–N1) - You are eligible for definitive (curative) radiation therapy, with or without chemotherapy - You are 18 or older and in acceptable overall health **You may NOT be eligible if...** - You have had prior chemotherapy, radiation, or surgery for anal cancer - You have had prior radiation to the pelvic/abdominal area that would overlap with current treatment - You have active inflammatory bowel disease (Crohn's or ulcerative colitis) or connective tissue disease Talk to your doctor to see if this trial is right for you.