RecruitingPhase 1NCT06070649
The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)
Sponsor
Yale University
Enrollment
63 participants
Start Date
Aug 4, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
This proposed study is a double-blind, randomized, placebo-controlled, parallel-group, laboratory study to determine the effects of DMT, plus psychotherapy, on Alcohol Use Disorder.
Eligibility
Min Age: 21 YearsMax Age: 65 Years
Inclusion Criteria3
- Diagnostic and Statistical Manual of Mental Disorders-5th edition (DSM-5) diagnosis of Alcohol Use Disorder
- Medically healthy
- Ability to provide consent
Exclusion Criteria1
- Unstable medical conditions
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Interventions
DRUG0.3mg/kg/min Dimethyltryptamine + Normal Saline infusion
Infusion
DRUG0.2 mg/kg/min + Dimethyltryptamine 0.01mg/kg/min infusion
Infusion
DRUG25 mg Diphenhydramine (5 min) + Normal Saline
Infusion
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06070649
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