The Swedish BioFINDER - Primary Care Study
Skane University Hospital
1,200 participants
Jan 1, 2020
OBSERVATIONAL
Conditions
Summary
The overall aim of the study is to improve the diagnostic accuracy of AD and cognitive impairment in primary care settings to ensure better care and treatment as well as facilitate correct referrals to specialized memory clinics. The investigators will strive to recruit diverse and representative populations of patients with subjective cognitive decline (SCD), mild cognitive impairment (MCI) and mild dementia. The specific aims of the study are to: 1. Improve the detection of mild cognitive impairment (MCI) and dementia in primary care. 2. Develop and evaluate cognitive tests, blood-based biomarkers and brain imaging methods that are suitable for accurate and early diagnosis of Alzheimer's disease (AD) in primary care. 3. To prospectively validate plasma AD biomarkers for diagnosis of patients with cognitive symptoms who are evaluated in primary care. 4. Determine whether blood AD biomarkers improve patient management in primary care.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
APS 2 score (combination of ptau217/nptau217 and Ab42/Ab40). The cut off will be predefined. The samples will be analysed prospectively every two weeks.
The cut off will be predefined. The samples will be analysed prospectively every two weeks.
The cut off will be predefined. The samples will be analysed prospectively every two weeks.
The cut off will be predefined. The samples will be analysed prospectively every two weeks.
The cut off will be predefined. The samples will be analysed prospectively every two weeks.
Structural brain imaging
Both standard paper-and-pen tests as well as digital cognitive tests will be evaluated.
Locations(1)
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NCT06120361