Frontotemporal Degeneration Clinical Trials

12 recruitingLast updated: June 18, 2026

There are 12 actively recruiting frontotemporal degeneration clinical trials across 6 countries. Studies span Not Applicable, Phase 1, Phase 2. Top locations include Malmö, Sweden, Edmonton, Alberta, Canada, Houston, Texas, United States. Updated daily from ClinicalTrials.gov.


Frontotemporal Degeneration Trials at a Glance

12 actively recruiting trials for frontotemporal degeneration are listed on ClinicalTrialsFinder across 6 cities in 6 countries. The largest study group is Not Applicable with 5 trials, with the heaviest enrollment activity in Malmö, Edmonton, and Houston. Lead sponsors running frontotemporal degeneration studies include Skane University Hospital, Johns Hopkins University, and Istituto Auxologico Italiano.

Browse frontotemporal degeneration trials by phase

Treatments under study

About Frontotemporal Degeneration Clinical Trials

Looking for clinical trials for Frontotemporal Degeneration? There are currently 8 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Frontotemporal Degeneration trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Frontotemporal Degeneration clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 112 of 12 trials

Recruiting
Not Applicable

Social & Affective Cognition in Alzheimer's Disease & Associated Disorders

Alzheimer s DiseaseFrontotemporal Degeneration (Semantic & Behavioral Variants)
University Hospital, Lille120 enrolled1 locationNCT06338397
Recruiting
Not Applicable

A Multifocal tDCS-EEG Protocol for Improving Symptoms of Mild Cognitive Impairment and Early Dementia

DementiaAlzheimer DiseaseAlzheimer Disease, Early Onset+3 more
University of Campania Luigi Vanvitelli50 enrolled1 locationNCT06668610
Recruiting

Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS

Amyotrophic Lateral SclerosisPrimary Lateral SclerosisProgressive Muscular Atrophy+1 more
University of Alberta150 enrolled4 locationsNCT05204017
Recruiting
Not Applicable

The Swedish BioFINDER 2 Study

DementiaMultiple System AtrophyAlzheimer Disease+10 more
Skane University Hospital2,950 enrolled2 locationsNCT03174938
Recruiting

The Swedish BioFINDER - Memory Clinic Study

Alzheimer DiseaseMild Cognitive ImpairmentLewy Body Disease+4 more
Skane University Hospital1,200 enrolled1 locationNCT06122415
Recruiting

The Swedish BioFINDER - Primary Care Study

Alzheimer DiseaseMild Cognitive ImpairmentLewy Body Disease+4 more
Skane University Hospital1,200 enrolled1 locationNCT06120361
Recruiting
Not Applicable

Social-cognitive Functioning: Validation of a New Neuropsychological Test

Frontotemporal Degeneration(FTD)Alzheimer's Disease(AD)Lewy Body Dementia (LBD)
Assistance Publique - Hôpitaux de Paris120 enrolled1 locationNCT05558709
Recruiting
Phase 2

Vortioxetine for the Treatment of Mood and Cognitive Symptoms in Frontotemporal Dementia

fronto-temporal dementiaFrontotemporal DementiaFrontotemporal Degeneration+3 more
Johns Hopkins University50 enrolled1 locationNCT06604520
Recruiting

UPenn Observational Research Repository on Neurodegenerative Disease

Corticobasal Syndrome(CBS)Progressive Supranuclear Palsy (PSP)Primary Progressive Aphasia(PPA)+6 more
University of Pennsylvania1,000 enrolled1 locationNCT04715399
Recruiting
Phase 1

IL-2 Plus Abatacept in FTD

Frontotemporal Degeneration
The Methodist Hospital Research Institute10 enrolled1 locationNCT06395038
Recruiting
Not Applicable

Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults

DementiaCognitive DysfunctionCognitive Decline+8 more
Universidade Federal do Rio de Janeiro40 enrolled1 locationNCT06733714
Recruiting

Advances in Telephone-based Cognitive Screening Procedures

Amyotrophic Lateral SclerosisCerebrovascular DisordersAlzheimer s Disease+2 more
Istituto Auxologico Italiano280 enrolled1 locationNCT06337578