RecruitingNot ApplicableNCT06130735

Impact of Intensive Computerized Cognitive Training

Computerized Cognitive Training: Characterization of Factors That Predict Cognitive Enhancement in Acquired Brain Injury

Sponsor

Brigham and Women's Hospital

Enrollment

30 participants

Start Date

Oct 1, 2023

Study Type

INTERVENTIONAL

Conditions

Mild Neurocognitive Disorder Mild Cognitive Impairment Acquired Brain Injury

Summary

To investigate factors that predict cognitive enhancement following engagement in an intensive Computerized Cognitive Training Protocol.

Eligibility

Min Age: 25 YearsMax Age: 65 Years

Inclusion Criteria6

Patient of the Mass General Brigham Health System with primary attention and executive functioning difficulties and/or a diagnosis of mild cognitive disorder or mild neurocognitive disorder (non-amnestic profile), due to an acquired brain injury (ABI) sustained at least 12 months prior to study contact.
Ages 25-65 years old
Proficiency in English
Willing and able to complete all study-related activities for 12 months, including travel to Brigham and Women's Hospital (Boston) for four in-person assessment visits and two serum and saliva sample collections.
Access to a computer with webcam and stable internet.
A reliable study informant who can complete one questionnaire about participant's cognition/daily functioning, at four time points.

Exclusion Criteria9

History of alcohol or substance abuse, or dependence, within the past 2 years, as per DSM-5 criteria.
High likelihood of an underlying progressive neurodegenerative disorder.
Evidence of moderate to severe cognitive disorder, based on a score of 21 or less on the Mini-Mental Status Examination (MMSE) (Tombaugh \& McIntyre, 1992).
Patient Health Questionnaire (PHQ)-9 (Kroenke et al., 2010) Score ≥ 19, unless deemed by treating provider not to have active depression (e.g., adjustment disorder, grief reaction).
Active psychotic symptoms.
Severe sensory losses such that participants would unlikely be able to participate in the study training, even with substantial accommodations (self-report of extreme difficulty reading ordinary newspaper print or a performance-tested corrected vision test score of worse than 20/30).
Communication difficulties that prevent the participant from effectively participating in this highly interactive study protocol (based on interviewer's rating of a person's ability to be understood and to understand others).
Current participation in a pharmacological, or other interventional research trial.
Life expectancy of \< 2 years.

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Interventions

BEHAVIORALCognitive Computerized Training

Participants will log into ABI Wellness Platform five days per week (M-T-W-Th-F) and train using the Symbol Relations module for 45 to 60 minutes. Every other week, participants will meet with their training facilitator via zoom to review training progress and troubleshoot any training-related questions.