RecruitingNot ApplicableNCT06137807

TRIcvalve biCAVal Valve System for Severe Tricuspid Regurgitation (TRICAV-I)

A Prospective, Multicenter Clinical Trial of the TricValve® Transcatheter Bicaval Valve System in Subjects With Severe Tricuspid Regurgitation - TRICAV-I Trial


Sponsor

P+F Products + Features USA Inc.

Enrollment

50 participants

Start Date

Jul 23, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The TricValve® Transcatheter Bicaval Valve System is a bicaval transcatheter tricuspid valve replacement system, which includes the TricValve® Transcatheter Bicaval Valve for superior vena cava (SVC) and the TricValve® Transcatheter Bicaval Valve for inferior vena cava (IVC). The TricValve® Transcatheter Bicaval Valves are pre-mounted into the TricValve® Delivery System which is used for percutaneous access and delivery of the TricValve® Transcatheter Bicaval Valve in the vena cava. The system is a single use, sterile device compatible with all the valve sizes. The prostheses are implanted percutaneously into the inferior and superior vena cava without disturbing the native tricuspid valve. The device is made of bovine pericardium leaflets sutured on a nitinol self-expanding stent system.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating a new heart valve system called the TRIcvalve biCAVal device in people with severe tricuspid regurgitation — a condition where the tricuspid valve in the heart leaks badly, causing blood to flow the wrong way. The device is implanted in the large veins (vena cava) that feed into the heart, without open-heart surgery. **You may be eligible if...** - You are 18 or older - You have severe tricuspid regurgitation confirmed by an echocardiogram (heart ultrasound) - You have significant heart failure symptoms (NYHA Class III or IVa) or were hospitalized for heart failure in the past 6 months - You have been on optimal medical therapy (including a water pill/diuretic) for at least 30 days - The local heart team has determined you are a good candidate for this device **You may NOT be eligible if...** - Your heart failure is so severe you need IV heart medications, a balloon pump, or a heart assist device - You are not considered a suitable candidate by the heart team - You have not been on optimal medical therapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICETricValve® Transcatheter Bicaval Valve System

The TricValve® Transcatheter Bicaval Valve System is a bicaval transcatheter tricuspid valve replacement system, which includes the TricValve® Transcatheter Bicaval Valve for superior vena cava (SVC) and the TricValve® Transcatheter Bicaval Valve for inferior vena cava (IVC). The system is a single use, sterile device compatible with all the valve sizes. The valves are premounted in the TricValve® Delivery System. The prostheses are implanted percutaneously into the inferior and superior vena cava without disturbing the native tricuspid valve. The device is made of bovine pericardium leaflets sutured on a nitinol self-expanding stent system available in sizes 25 and 29 for superior vena cava and 31 and 35 for inferior vena cava. The valve is implanted percutaneously by the transfemoral approach. The valves are supplied already premounted into the TricValve® Delivery System.


Locations(36)

St. Joseph's Hospital and Medical Center

Phoenix, Arizona, United States

Tucson Medical Center

Tucson, Arizona, United States

Scripps Memorial Hospital La Jolla

San Diego, California, United States

UCSF

San Francisco, California, United States

Delray Medical Center

Delray Beach, Florida, United States

Largo Medical Center

Largo, Florida, United States

Tampa General Hospital

Tampa, Florida, United States

Endeavor Health, Glenbrook Hospital

Glenview, Illinois, United States

Chicago Advocate Christ

Palos Park, Illinois, United States

Ascension Medical Group St. Vincent The Heart Center of Indiana

Indianapolis, Indiana, United States

Cardiovascular Institute of the South

Houma, Louisiana, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

Lahey Hospital & Medical Center

Burlington, Massachusetts, United States

Minneapolis Heart Institute Foundation

Minneapolis, Minnesota, United States

Saint Luke's Mid America Heart Institute

Kansas City, Missouri, United States

Washington University St Louis

St Louis, Missouri, United States

Hackensack University Medical Center

Hackensack, New Jersey, United States

North Shore University Hospital

Manhasset, New York, United States

Montefiore Medical Center

The Bronx, New York, United States

Duke Cardiology Clinic

Durham, North Carolina, United States

Cleveland Clinic

Cleveland, Ohio, United States

Riverside Methodist Hospital

Columbus, Ohio, United States

Oregon Health Services

Portland, Oregon, United States

UPMC Pinnacle

Harrisburg, Pennsylvania, United States

UPMC Presbyterian Shadyside

Pittsburgh, Pennsylvania, United States

WellSpan York Hospital

York, Pennsylvania, United States

MUSC

Charleston, South Carolina, United States

Houston Methodist

Houston, Texas, United States

University of Texas (Memorial Hermann)

Houston, Texas, United States

Intermountain Heart Institute - Intermountain Medical Center

Murray, Utah, United States

UVA School of Medicine

Charlottesville, Virginia, United States

Sentara Healthcare

Norfolk, Virginia, United States

Carilion Clinic

Roanoke, Virginia, United States

MedStar Washington Hospital Center

Multiple Locations, Washington, United States

Swedish Medical Center

Seattle, Washington, United States

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NCT06137807


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