Tricuspid Valve Disease Clinical Trials

12 recruitingLast updated: May 21, 2026

There are 12 actively recruiting tricuspid valve disease clinical trials across 17 countries. Studies span Not Applicable. Top locations include Indianapolis, Indiana, United States, The Bronx, New York, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Tricuspid Valve Disease Trials at a Glance

12 actively recruiting trials for tricuspid valve disease are listed on ClinicalTrialsFinder across 6 cities in 17 countries. The largest study group is Not Applicable with 8 trials, with the heaviest enrollment activity in Indianapolis, The Bronx, and New York. Lead sponsors running tricuspid valve disease studies include Corvivo Cardiovascular, Inc., VDyne, Inc., and Chelyabinsk Regional Clinical Hospital.

Browse tricuspid valve disease trials by phase

About Tricuspid Valve Disease Clinical Trials

Looking for clinical trials for Tricuspid Valve Disease? There are currently 12 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Tricuspid Valve Disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Tricuspid Valve Disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 112 of 12 trials

Recruiting
Not Applicable

EFS of the DUO System for Tricuspid Regurgitation

Tricuspid RegurgitationHeart Valve DiseasesTricuspid Valve Insufficiency+1 more
CroiValve Limited15 enrolled16 locationsNCT05913908
Recruiting
Not Applicable

Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Tricuspid RegurgitationTricuspid Valve InsufficiencyTricuspid Valve Disease
Edwards Lifesciences1,270 enrolled79 locationsNCT04097145
Recruiting
Not Applicable

Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacement System for the Treatment of Tricuspid Regurgitation ( VISTA-US)

Tricuspid RegurgitationTricuspid Valve DiseaseTricuspid Valvular Disorders
VDyne, Inc.30 enrolled11 locationsNCT05848284
Recruiting

Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease

Aortic Valve DiseaseHeart Valve DiseaseTricuspid Valve Regurgitation+11 more
Second Affiliated Hospital, School of Medicine, Zhejiang University10,000 enrolled15 locationsNCT07267117
Recruiting
Not Applicable

Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacement System for the Treatment of Tricuspid Regurgitation

Tricuspid RegurgitationTricuspid Valve DiseaseTricuspid Valvular Disorders
VDyne, Inc.120 enrolled21 locationsNCT05797519
Recruiting
Not Applicable

CorMatrix Cor TRICUSPID ECM Valve Replacement Study

Tricuspid Valve Disease
Corvivo Cardiovascular, Inc.78 enrolled4 locationsNCT02397668
Recruiting
Not Applicable

CorMatrix Cor TRICUSPID ECM Valve Replacement - Pivotal Study

Tricuspid Valve InsufficiencyTricuspid Valve Disease
Corvivo Cardiovascular, Inc.92 enrolled2 locationsNCT05742906
Recruiting
Not Applicable

TRIcvalve biCAVal Valve System for Severe Tricuspid Regurgitation (TRICAV-I)

Tricuspid RegurgitationTricuspid Valve Disease
P+F Products + Features USA Inc.50 enrolled36 locationsNCT06137807
Recruiting

Clinical Efficacy and Long-term Outcomes of ALLOgraft Versus Stented Biological Prosthesis for Primary TRIcuspid Valve Disease (ALLOTRI)

Tricuspid Valve DiseaseAllograftBioprosthesis
Chelyabinsk Regional Clinical Hospital56 enrolled1 locationNCT06591000
Recruiting
Not Applicable

The Effects of 360-degree Virtual Reality on Pre-procedural Anxiety in Patients Awaiting Elective Cardiac Surgery Involving a Sternotomy

Aortic Valve DiseaseTricuspid Valve DiseaseMitral Valve Disease+1 more
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)100 enrolled1 locationNCT06001489
Recruiting

European Association of Cardiovascular Imaging Multiple and Mixed Valvular Disease Study

Aortic Valve DiseaseHeart Valve DiseasesTricuspid Valve Insufficiency+11 more
Assistance Publique - Hôpitaux de Paris1,500 enrolled1 locationNCT06235385
Recruiting

PROMISE: Percutaneous peRipheral cannulatiOn for Minimally-InvaSive Heart Valve surgEry

Aortic Valve DiseaseHeart Valve DiseasesTricuspid Valve Disease+1 more
Universitätsklinikum Hamburg-Eppendorf1,000 enrolled1 locationNCT05961150