RecruitingNCT06166706

Current Practice of Ventilation Strategies in Children Undergoing General Anesthesia

Current Practice of Ventilation Strategies in Children Undergoing General Anesthesia and Associations With Postoperative Pulmonary Complications - a Multicenter Prospective Cohort Study


Sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Enrollment

10,000 participants

Start Date

Jan 29, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Postoperative pulmonary complications (PPCs) are common in children undergoing general anesthesia and are associated with prolonged stay in the hospital and high costs. Development of PPCs is associated with ventilator settings in adult patients undergoing general anesthesia. Data on perioperative ventilator settings in children are lacking, leaving the anaesthetist without guidance. Consequently, the current standard of care in perioperative mechanical ventilation in children is expected to be extremely heterogeneous, leading to ventilation with higher levels of energy than necessary. Therefore, it is highly necessary to evaluate the current practice in perioperative ventilation in children and to determine associations with PPCs.


Eligibility

Max Age: 16 Years

Inclusion Criteria4

  • aged ≤ 16 years;
  • undergoing general anesthesia
  • airway management with tube or LMA; and
  • connected to mechanical ventilator . minimum duration of procedure: 15 minutes

Exclusion Criteria4

  • patients undergoing surgical procedures involving extra-corporal circulation;
  • patients receiving ventilation with high frequency jet ventilation or high frequency oscillatory ventilation;
  • sedation without airway management in the form of a endotracheal tube or a supraglottic airway device; and
  • (rigid) bronchoscopic procedures with maintenance of spontaneous ventilation.

Locations(4)

Perth Children's Hospital

Perth, Australia

IRCCS Istituto Giannina Gaslini

Genoa, Italy

Amsterdam University Medical Centers

Amsterdam, Please Select, Netherlands

Universitatsspital Bern

Bern, Switzerland

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NCT06166706