Multiphase Optimization Strategy (MOST) for Treating Pediatric Post-traumatic Stress Disorder (PTSD)
Optimizing Behavioral Health Services Following Pediatric Trauma Exposure
University of Rochester
200 participants
Mar 15, 2026
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to test the extent to which different treatment components work to improve pediatric post-traumatic stress disorder (PTSD). It will also provide evidence for how these components work. The main research questions are: What are the effects of different components used to treat PTSD? What do these components change to produce benefits in PTSD? Researchers will: Compare components to a psychological placebo to estimate their effects and measure how they work Examine how components work alone and in conjunction with other components Participants will: Receive different combinations of components and placebo Attend weekly treatment sessions Provide information to evaluate changes in PTSD
Eligibility
Plain Language Summary
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This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
Participants learn to reduce acute subjective distress, stabilize negative mood, promote positive mood, and alter physiological responses to trauma
Participants engage in written exercises to reduce avoidance of trauma reminders and reinforce approach behaviors consistent with personal goals
Participants learn ways to identify, challenge, and overcome the influence of cognitive distortions resulting from trauma exposure
Participants engage in horizontal eye movements while recalling a traumatic memory and describing their affective and physiological state
Participants receive non-directive support therapy, where they will guide the treatment session but not be required to discuss prior trauma exposure
Locations(1)
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NCT06956781