RecruitingNot ApplicableNCT06956781

Multiphase Optimization Strategy (MOST) for Treating Pediatric Post-traumatic Stress Disorder (PTSD)

Optimizing Behavioral Health Services Following Pediatric Trauma Exposure


Sponsor

University of Rochester

Enrollment

200 participants

Start Date

Mar 15, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to test the extent to which different treatment components work to improve pediatric post-traumatic stress disorder (PTSD). It will also provide evidence for how these components work. The main research questions are: What are the effects of different components used to treat PTSD? What do these components change to produce benefits in PTSD? Researchers will: Compare components to a psychological placebo to estimate their effects and measure how they work Examine how components work alone and in conjunction with other components Participants will: Receive different combinations of components and placebo Attend weekly treatment sessions Provide information to evaluate changes in PTSD


Eligibility

Min Age: 8 YearsMax Age: 17 Years

Plain Language Summary

Simplified for easier understanding

This study is working to find the best combination of therapy techniques for children and teenagers who have PTSD (post-traumatic stress disorder) after experiencing a traumatic event. Researchers are testing different treatment approaches — delivered partly via smartphone app — to figure out which combination works best for kids. **You may be eligible if...** - Your child is between 8 and 17 years old - Your child has experienced at least one traumatic event and meets the diagnostic criteria for PTSD - You are the caregiver with legal custody and can provide parental permission - Your child and family are willing to participate in therapy and complete surveys - Your child can read and understand English - Your child is in a stable home environment - If your child takes psychiatric medication, the dose has not changed in the past 2 months - You and/or your child have a smartphone that can download an app **You may NOT be eligible if...** - Your child does not meet PTSD diagnostic criteria - Your child is not in a stable living situation or a change is expected soon - You are not able to participate in treatment sessions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALEmotion Regulation

Participants learn to reduce acute subjective distress, stabilize negative mood, promote positive mood, and alter physiological responses to trauma

BEHAVIORALExposure

Participants engage in written exercises to reduce avoidance of trauma reminders and reinforce approach behaviors consistent with personal goals

BEHAVIORALCognitive Processing

Participants learn ways to identify, challenge, and overcome the influence of cognitive distortions resulting from trauma exposure

BEHAVIORALBi-lateral Stimulation

Participants engage in horizontal eye movements while recalling a traumatic memory and describing their affective and physiological state

BEHAVIORALPsychological Placebo

Participants receive non-directive support therapy, where they will guide the treatment session but not be required to discuss prior trauma exposure


Locations(1)

The Mt. Hope Family Center

Rochester, New York, United States

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NCT06956781


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