RecruitingNCT06181409

LSM and SSM for the Diagnosis of CSPH: a Prospective Cohort Study

Diagnosing and Monitoring Portal Hypertension Non-invasively Using Spleen Stiffness Measurement in Patients With Advanced Chronic Liver Disease: a Prospective Cohort Study

Sponsor

McGill University Health Centre/Research Institute of the McGill University Health Centre

Enrollment

200 participants

Start Date

Jan 10, 2024

Study Type

OBSERVATIONAL

Conditions

Advanced Chronic Liver Disease

Summary

The goal of this observational study is to assess non-invasive tools' efficacy in predicting portal hypertension-related complications in individuals with advanced chronic liver disease. The main question it aims to answer are: \- what are the cut-off values for non-invasive tests (NITs) (including LSM, SSM) that predict the presence and occurrence of hepatic decompensation in individuals with advanced chronic liver disease? Participants will undergo regular study visits involving non-invasive tests (LSM, SSM) and assessments to monitor hepatic decompensation over the study period.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study uses liver stiffness measurements (done non-invasively through ultrasound) to diagnose clinically significant portal hypertension (CSPH) — a serious complication of advanced liver disease where pressure builds up in the large blood vessel feeding the liver. High pressure in this vessel can lead to dangerous complications like internal bleeding. The study validates whether ultrasound measurements alone can accurately detect this condition without needing an invasive procedure. **You may be eligible if...** - You are 18 or older - You have been diagnosed with advanced chronic liver disease (liver stiffness ≥10 kPa on prior testing) - You are able to provide informed consent **You may NOT be eligible if...** - You have already had a TIPS procedure (a tube placed in the liver's blood vessels) - You have had a liver transplant - You have abnormalities in the blood vessels connecting the intestine to the liver - You have had a recent liver procedure that might affect measurements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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