Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer

This study matches children and young adults with difficult-to-treat cancers to personalized therapies based on their tumor's genetic profile. It is an "umbrella" trial offering multiple targeted treatments depending on each patient's specific cancer mutations. **You may be eligible if...** - You are under 21 years old (or have a pediatric-type cancer if slightly older, with approval) - You have a solid tumor, brain tumor, or lymphoma that has progressed despite standard treatment, or for which no standard treatment exists - You are enrolled in a precision medicine genomic study (such as PROFYLE or ZERO) **You may NOT be eligible if...** - You have not undergone genomic testing as part of a qualifying precision medicine program - You are too unwell to tolerate treatment - Your cancer type does not match any available treatment arms in the study Talk to your doctor to see if this trial is right for you.