RecruitingNCT06234410

Cardiovascular Risk Assessment For Kidney Transplantation - Utility of Computed Tomography Coronary Angiography in the Assessment of Patients Awaiting Kidney Transplantation


Sponsor

University of Edinburgh

Enrollment

332 participants

Start Date

Jan 24, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Cardiovascular disease (for example, heart attack, stroke, heart failure) is the commonest complication of kidney failure. Kidney transplantation reduces cardiovascular risk but cardiovascular disease remains the commonest cause of death in patients following transplantation. Current strategies to assess patient's cardiovascular risk prior to kidney transplantation do not identify those at highest risk and do not improve outcomes. This study will use a heart scan known as computed tomography coronary angiography (CTCA) to see whether this scan can identify patients at highest risk of future cardiovascular disease prior to transplantation. Studies have shown it is able to do this in patients with normal kidney function. The aim of this study is to develop CTCA as an effective tool to risk stratify patients prior to kidney transplantation.


Eligibility

Min Age: 16 Years

Inclusion Criteria3

  • Has kidney failure and is on the waitlist for a kidney transplant
  • Age 16 years and over
  • Able to give informed consent

Exclusion Criteria3

  • Contraindication to CT scanning, including contrast allergy
  • Patients being considered for a simultaneous kidney-pancreas, kidney-liver and/or kidney-islet transplantation
  • Inability to give informed consent

Interventions

RADIATIONComputed tomography coronary angiography (CTCA)

Single CTCA scan prior to kidney transplantation


Locations(2)

Royal Infirmary of Edinburgh

Edinburgh, Lothian, United Kingdom

Queen Elizabeth Hospital

Glasgow, United Kingdom

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NCT06234410


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