Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery
The Effect of Intravenous Lidocaine or Ketamine on Interleukin-6 Levels in Patients Undergoing Colorectal Surgery for Cancer: A Randomized Controlled Trial
University Tunis El Manar
50 participants
Oct 1, 2023
INTERVENTIONAL
Conditions
Summary
Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta). For the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours. For the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours. Plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.
Eligibility
Inclusion Criteria11
- Patients aged 18 or older.
- American society of anesthesiologists' (ASA) physical status of I-III.
- Elective open colorectal surgery.
- Patients with contraindications to lidocaine or ketamine.
- Corticosteroid therapy within the last 6 months.
- History of immunosuppressive therapy.
- History of surgery in the last 3 months.
- Personal medical history of inflammatory bowel disease.
- Personal medical history of cardiac arrythmias or conduction disorders.
- Alcohol or drug abuse.
- Chronic use of opioids or benzodiazepines.
Exclusion Criteria2
- Severe intraoperative complications.
- Duration of surgery longer than 5 hours.
Interventions
Intravenous Lidocaine Vs intravenous Ketamine in colorectal surgery for cancer
Intravenous Lidocaine Vs intravenous Ketamine in colorectal surgery for cancer
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06272461