RecruitingNot ApplicableNCT06272461

Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery

The Effect of Intravenous Lidocaine or Ketamine on Interleukin-6 Levels in Patients Undergoing Colorectal Surgery for Cancer: A Randomized Controlled Trial

Sponsor

University Tunis El Manar

Enrollment

50 participants

Start Date

Oct 1, 2023

Study Type

INTERVENTIONAL

Conditions

Colorectal (Colon or Rectal) Cancer Inflammation

Summary

Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta). For the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours. For the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours. Plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two pain-control medications — intravenous lidocaine and ketamine — given during colorectal (bowel) surgery to see which one better reduces pain, inflammation, and recovery time after the operation. **You may be eligible if...** - You are 18 or older - You are having planned (non-emergency) open colorectal surgery - Your overall health is classified as ASA I–III (mild to moderate health conditions) **You may NOT be eligible if...** - You have a known reaction to lidocaine or ketamine - You have used corticosteroids or immunosuppressive drugs in the last 6 months - You have a history of irregular heart rhythms, bowel disease, alcohol or drug abuse, or regular opioid or sedative use Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGLidocaine IV

Intravenous Lidocaine Vs intravenous Ketamine in colorectal surgery for cancer

DRUGKetamine Injectable Solution

Intravenous Lidocaine Vs intravenous Ketamine in colorectal surgery for cancer

Locations(1)

Tunisia

Nabeul, Tunisia

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NCT06272461

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