RecruitingNCT06292897

Using Tissue-based Spatial Data to Understand How Obesity-related Tumor Metabolites Fuel Prostate Cancer Progression

Integrating Tissue-based Spatial Information to Elucidate How Obesity-induced Tumour Metabolites Drive Prostate Cancer Progression

Sponsor

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Enrollment

25 participants

Start Date

Mar 20, 2023

Study Type

OBSERVATIONAL

Conditions

Prostate Cancer Obesity Prostate Neoplasm Prostatic Neoplasm Prostate Adenocarcinoma

Summary

Evaluate the protein expression of lactate dehydrogenase enzyme (LDHA) and MCT-1/-4 transporters, involved in lactate synthesis and transport, in prostate carcinoma tissues from severely overweight/obese (BMI \> 27.5) and non-severely overweight/normoweight (BMI \< 27.5) patients affected by prostate carcinoma. ii. Characterize the immune infiltrate in the prostate carcinoma of the aforementioned patients. iii. Assess the association between intra-tumoral lactate accumulation (using LDHA and MCT-4 protein expression levels as readouts) and alterations in the tumor immune microenvironment and/or deregulation of relevant oncogenic pathways.

Eligibility

Sex: MALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is using advanced tissue analysis to understand how obesity affects prostate cancer at a molecular level. Researchers are looking at how fat-related metabolites (chemical byproducts of fat metabolism) that are elevated in obese patients may fuel prostate cancer growth and help the cancer progress to more aggressive stages. The findings could lead to new treatment strategies that target these metabolic pathways. **You may be eligible if...** - You have been diagnosed with prostate cancer - You are willing to provide tissue samples for laboratory analysis **You may NOT be eligible if...** - You have not been diagnosed with prostate cancer - You are unwilling to provide tissue samples for research This is a tissue and data-based research study. No specific additional exclusion criteria were listed by the study team. Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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