RecruitingNCT06306963

Prevalence of Gastric Motor Dysfunction and Upper GI Symptoms in Gastric Antral Vascular Ectasias

Sponsor

Mayo Clinic

Enrollment

30 participants

Start Date

Mar 22, 2024

Study Type

OBSERVATIONAL

Conditions

Cirrhosis Chronic Kidney Disease Gastric Antral Vascular Ectasia

Summary

The researchers are trying to find out more about Gastric Antral Vascular Ectasia (GAVE). This is a condition that affects the blood vessels in the stomach, leading to their enlargement and possible bleeding. It can also cause symptoms such as abdominal pain and nausea. By participating in this study, you will help us learn how often these symptoms occur and how they relate to stomach functioning.

Eligibility

Min Age: 19 Years

Plain Language Summary

Simplified for easier understanding

This study investigates how often people with a stomach condition called gastric antral vascular ectasia (GAVE) — also known as "watermelon stomach" due to its appearance on endoscopy — also have problems with stomach emptying and related digestive symptoms. **You may be eligible if...** - You are over 18 years old - A recent endoscopy has confirmed you have gastric antral vascular ectasia (GAVE) - You are willing to participate and can give informed consent - Your symptoms are not explained by another known disease **You may NOT be eligible if...** - You need blood transfusions due to ongoing blood loss - You have severe liver disease - You have end-stage kidney disease - You are pregnant or breastfeeding - You drink heavily - You have not had a recent blood count test (within the past 6 months) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTGastric Emptying Breath Test

13C-Spirulina GEBT (Cairn Diagnostics) is non-radioactive, non-invasive breath based test validated against scintigraphy for the measurement of gastric emptying. Patients will be mailed test kits to be done in their homes remotely along with telehealth assistance from the study team. After overnight fast and providing duplicate pre-meal breath samples, the patient consumes 27 grams of re-hydrated, precisely formulated, pasteurized scrambled egg mix containing a dose of 43 mg of 13C (provided by approximately 100 mg of 13C-Spirulina), 6 saltine crackers and 6 ounces (180 mL) of potable water. The caloric value of the meal is approximately 230 kCal.Patient will provide breath samples into provided glass tubes before and after test meal administration which are then mailed back to a central laboratory for analysis by gas isotope ratio mass spectrometry.