Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury
Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury: Randomized Controlled Trial
University of Colorado, Denver
1,100 participants
May 19, 2025
INTERVENTIONAL
Conditions
Summary
The objective is to determine the effectiveness of pulsatile flow during cardiopulmonary bypass to reduce the incidence of acute kidney injury after cardiac surgery. Investigators will also evaluate the safety and impact of pulsatile flow on clinical outcomes compared to non-pulsatile flow during cardiopulmonary bypass.
Eligibility
Inclusion Criteria2
- Able to provide informed consent
- Scheduled for elective cardiac surgery with cardiopulmonary bypass
Exclusion Criteria9
- Emergency procedures
- Scheduled for heart or lung transplantation
- Scheduled for ventricular assist device implantation
- Use of the Medtronic Elongated Once-Piece Arterial Cannula
- Diagnosed with sepsis
- Diagnosed with delirium
- Experiencing hemodynamic instability (heart rate > 100 and systolic blood pressure < 90)
- Requiring mechanical circulatory support
- Requiring vasoactive medications
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Non-pulsatile blood flow generated by constant centrifugal pump flow rate during cardiopulmonary bypass
Pulsatile blood flow generated by variable centrifugal pump flow rate during cardiopulmonary bypass
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06349577