PRORAD-5 PROstate RADiation in 5 Fractions: Phase II Five Fraction Radiotherapy for Patients With Advanced Prostate Cancer.

This Phase II study is testing whether delivering radiation to the whole prostate in just 5 treatment sessions (instead of the usual 40+) is safe and effective for men with advanced prostate cancer who have specific risk features. **You may be eligible if...** - You have a confirmed diagnosis of prostate adenocarcinoma within the past year - Your cancer is classified as intermediate or high risk (Gleason grade group 2 or higher, or PSA in a specific range) - Your cancer is locally confined or regionally advanced but meets specific staging criteria - You have adequate performance status and organ function **You may NOT be eligible if...** - Your cancer has spread to distant organs (metastatic) - You have had prior pelvic radiation therapy - You have significant urinary problems or other conditions that make prostate radiation unsafe - You are unable to complete the required follow-up Talk to your doctor to see if this trial is right for you.