The Effect of Alcohol on Common Tremor Syndromes
The Effect of Alcohol on Common Tremor Syndromes - A Prospective Double-blind Randomised Cross-over (Alcohol, Placebo) Study
Medical University of Graz
45 participants
May 1, 2024
INTERVENTIONAL
Conditions
Summary
The aim of this interventional study is to compare the response to alcohol in patients with essential tremor (ET), essential tremor plus (ETplus), dystonic tremor (DT), tremor associated with dystonia (TaD) and tremor in Parkinson´s disease (PD). The main question to be answered is: • Is there a difference in the objective alcohol responsiveness of patients with ET, DT, TaD and PD? Participants will receive either vodka with rum-flavoured orange juice with a target blood alcohol of 0.4 ‰ or a non-alcoholic rum-flavoured orange juice (vice versa on the second study day). Before and 30, 60 an 120 minutes after the study drink the participants will undergo a clinical examination of the tremor and accelerometry will be performed. Researchers will compare alcohol and placebo in a randomized cross over way to see if the effect of alcohol on tremor exceeds the placebo effect.
Eligibility
Inclusion Criteria3
- diagnosis of PD, DT, TaD, ET or ETplus based on clinical diagnostic criteria
- tremor in upper extremities
- accompanying person for both study visits
Exclusion Criteria4
- persons that are not willing to abstain from driving at both study days
- patients with diseases prohibiting alcohol ingestion
- patients with a history of alcohol abuse
- pregnancy
Interventions
Participants will receive vodka with rum flavored orange juice with a target blood alcohol of 0.4 ‰ 30 minutes after alcohol consumption. The required amount of vodka will be calculated with the Widmark formula.
Participants will receive a non-alcoholic rum flavored orange juice.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06403280