RecruitingNCT06448403

Multimodal Assesment of Alzheimer Patients

Multimodal Assessment of Cognitive Impairment in Alzheimer Patients


Sponsor

Norwegian University of Science and Technology

Enrollment

60 participants

Start Date

Jul 1, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this study is to learn more about the changes in the brains of patients with cognitive impairment (MCI) and Alzheimer's Disease (AD). The main questions the study aims to answer are: 1. What findings can be used to earlier detect patients that will develop Alzheimers? 2. Which differences are seen between healthy and cognitively impaired patients? 3. Which differences are seen between patients with Alzheimers disease? Participants will undergo: * Cognitive tests * Magnetic resonance imaging (MRI) * Electroencephalography (EEG) * Blood sample collection * Fecal sample collection * A randomized group will undergo polysomnography analysis.


Eligibility

Min Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study uses multiple types of brain assessments — including MRI and EEG — to better understand and track Alzheimer's disease and mild cognitive impairment (early memory and thinking problems). A healthy control group will also be included for comparison. **You may be eligible if...** - You have been diagnosed with mild cognitive impairment or Alzheimer's disease - You are aged 65 or older (early-onset Alzheimer's, before age 65, is excluded) - You are able to undergo MRI and EEG testing **You may NOT be eligible if...** - You have early-onset Alzheimer's (diagnosed before age 65) - You have a brain tumor, history of brain surgery, or traumatic brain injury - You have another neurological condition such as Parkinson's disease, ALS, or multiple sclerosis Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEMRI Scanning

MRI scanning with volumetric, resting and activity-based sequences.

DEVICE64-channel EEG

EEG to quantifiy electric activity.

DEVICEPolysomnography

A randomized group will undergo polysomnography.

BIOLOGICALBlood samples

Analysis of specific blood biomarkers.

BIOLOGICALFecal samples

Analysis of bacterial composition.

BEHAVIORALCognitive tests

Interview-based cognitive tests for assesment of cognitive levels.


Locations(1)

Norwegian University of Sciene and Technology / Norges teknisk-naturvitenskapelige universitet (NTNU)

Trondheim, Trønderlag, Norway

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NCT06448403


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