Dynamic Hormone Profiling and Multimodal Data Capture in Primary Aldosteronism
Haukeland University Hospital
80 participants
Jun 1, 2024
OBSERVATIONAL
Conditions
Summary
This study is a observational study applying 24-hour microdialysis methodology to perform dynamic multisteroid adrenal hormone profiling of patients with suspected or confirmed PA. Simultaneous registration of blood pressure, tissue glucose, sleep pattern, activity level and food intake registration may be performed. The overall objective is to develop a novel, sensitive, fast and user-friendly diagnostic procedure for PA, using multimodal data capture including dynamic multisteroid hormone profiling from microdialysis fluid.
Eligibility
Exclusion Criteria3
- Age <18 or > 70 years.
- Pregnancy.
- Known adrenal failure and/or on steroid therapy (oral, inhaled, parenteral or topical) or other interfering medication.
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Interventions
Included patients will perform 24-hour dynamic microdialysis sampling from subcutaneous tissue fluid of the lower abdomen, applying the U-Rhythm sampler. Simutaneous measurements of blood pressure, glucose, and registration of activity level, meals and sleep pattern during microdialysis sampling may be performed. Microdialysis sampling will be performed during various conditions: during daily life activities, during saline infusion suppression testing and during dexamethasone suppression testing. Repeated sampling may be performed post treatment.
Locations(1)
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NCT06495983