Additive Effects of Clonidine Used in Propofol Sedation in Colonoscopy
Tanta University
62 participants
Jul 20, 2024
INTERVENTIONAL
Conditions
Summary
The objective of this study was to compare safety, satisfaction, and efficiency outcomes of propofol versus propofol with clonidine in patients undergoing colonoscopy.
Eligibility
Inclusion Criteria4
- Age 18-65 years.
- Both sexes.
- American Society of Anesthesiology (ASA) physical status I-II.
- Patients undergoing colonoscopy.
Exclusion Criteria4
- Patients had recent history of colonoscopy.
- Previous colonic resection.
- Severe heart failure (ejection fraction \< 30%).
- Known history of hypersensitivity to propofol or clonidine and any need for anesthetic drug administration other than the study protocol.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Continuous propofol infusion will be given with syringe pump for maintenance, with the initial rate set at 25-75 mic/kg/min IV during the first 10-15 min. To avoid administering sedatives at rates greater than clinically necessary, infusion rates will be gradually titrated to 25-50 mic/kg/min and regulated with the clinical response, with an onset of peak drug action expected to occur within 2 min.
Patients will receive 2 μg/kg of clonidine for injection intravenously 30 min before induction of sedation, administered over 10 min.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06507410