A Phase I Clinical Study of Intratumoral Injection Oncolytic Vaccinia Virus GC001 in Patient With Advanced Solid Tumors

This is a Phase I study testing a new cancer treatment — a virus called GC001 that is engineered to infect and kill cancer cells (an oncolytic virus) — by injecting it directly into tumors. It is being tested in patients with advanced solid tumors that have not responded to other treatments. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with an advanced solid tumor (such as colorectal, lung, ovarian, or cervical cancer) confirmed by biopsy - Your cancer has progressed or you have not responded to standard treatments - You are in adequate overall health and your major organs are functioning well **You may NOT be eligible if...** - You have uncontrolled brain metastases - You have a serious autoimmune disease - You are on immunosuppressive medications - You have significant heart, liver, or kidney problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.