RecruitingNCT06512701

Study on the Correlation Between Fat Soluble Vitamins and Non-alcoholic Fatty Liver Disease

Sponsor

First Affiliated Hospital of Zhejiang University

Enrollment

4,000 participants

Start Date

Jul 3, 2024

Study Type

OBSERVATIONAL

Conditions

Non-Alcoholic Fatty Liver Disease Fat Soluble Vitamin Deficiencies and Disorders

Summary

Excessive or insufficient levels of vitamins in the body can affect health. With the prevalence of obesity and MetS, NAFLD has become the leading cause of chronic liver disease and abnormal liver biochemical indicators in health examinations in China. The current research results on serum vitamin A, D, and E levels in NAFLD patients are controversial. Therefore, this study mainly explores the correlation between serum FSV levels and NAFLD, providing reference for nutrition and clinical management of NAFLD patients.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Age ≥ 18 years old, both male and female;
Voluntarily participate in this study and sign an informed consent form;
Diagnosed NAFLD through abdominal ultrasound;

Exclusion Criteria6

Acute and chronic infections, severe cardiovascular and cerebrovascular diseases, respiratory system diseases, urinary system diseases, rheumatic diseases, tumors, and pituitary dysfunction; Or have hepatitis B, hepatitis C virus, or acquired immunodeficiency syndrome;
Surgery was performed within 6 months, and blood donation, transfusion, or significant blood loss occurred within 4 months;
Have taken vitamin supplements within 2 weeks;
Women are in pregnancy, lactation, or within one year after childbirth;
Alcohol abuse (alcohol intake ≥ 140 g/week for males and ≥ 70 g/week for females)
The serum creatinine (SCr) exceeds twice the following abnormal values, with the standard of abnormal values being: male (20-59 years old)>97 μ mol/L, male (60-79 years old)>111 μ mol/L; Female (20-59 years old)>73 μ mol/L, female (60-79 years old)>81 μ mol/L.