RecruitingNCT06514820

Exercise Magnetic Resonance Imaging in Patients With Obesity Associated Heart Failure

EXercise Magnetic Resonance Imaging in Patients With Obesity aSsociated Heart failURe With Preserved Ejection Fraction (EXPOSURE) Study

Sponsor

University Medical Center Groningen

Enrollment

50 participants

Start Date

Jan 16, 2024

Study Type

OBSERVATIONAL

Conditions

HFpEF - Heart Failure With Preserved Ejection Fraction

Summary

To aim of the EXPOSURE study is to investigate the effects of epicardial fat on cardiac function, pericardial constraint and pulmonary artery vasodilatation using cardiac magnetic resonance (CMR) imaging at rest and during exercise stress testing in patients with HFpEF.

Eligibility

Min Age: 18 Years

Inclusion Criteria7

Signs and symptoms of HF according to the Europeans Society of Cardiology guideline.
LV ejection fraction ≥40%.
HFA-PEFF score ≥5 or HFA-PEFF score 2-4 in combination with positive stress test (Figure 1).
\>18 years of age
In sinus rhythm
Able to perform a bicycle exercise test
Willing to sign informed consent

Exclusion Criteria6

Body weight \>140 kg
Atrial fibrillation or other significant arrhythmia during the assessment
Contraindications for CMR (e.g. claustrophobia, implanted cardiac devices)
Myocardial infarction, percutaneous coronary intervention or coronary artery bypass graft \<3 months or untreated severe obstructive coronary artery stenosis
More than moderate left-sided valve disease.
Complex congenital heart disease.