RecruitingNCT06514820

Exercise Magnetic Resonance Imaging in Patients With Obesity Associated Heart Failure

EXercise Magnetic Resonance Imaging in Patients With Obesity aSsociated Heart failURe With Preserved Ejection Fraction (EXPOSURE) Study


Sponsor

University Medical Center Groningen

Enrollment

50 participants

Start Date

Jan 16, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

To aim of the EXPOSURE study is to investigate the effects of epicardial fat on cardiac function, pericardial constraint and pulmonary artery vasodilatation using cardiac magnetic resonance (CMR) imaging at rest and during exercise stress testing in patients with HFpEF.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is using exercise MRI (cardiac MRI performed while the patient pedals a stationary bicycle) to better understand how the heart functions under stress in people with obesity-related heart failure with preserved ejection fraction (HFpEF), where the heart pumps normally but doesn't relax properly. **You may be eligible if...** - You are over 18 years old with signs and symptoms of heart failure - Your heart's pumping function (left ventricular ejection fraction) is 40% or above - Your heart failure score (HFA-PEFF) suggests preserved ejection fraction heart failure - You are in normal heart rhythm (sinus rhythm) - You are able to ride a bicycle for the exercise test - You are willing to sign informed consent **You may NOT be eligible if...** - You weigh more than 140 kg - You have atrial fibrillation or significant arrhythmias during testing - You have MRI contraindications (e.g., implanted devices, severe claustrophobia) - You have had a recent heart attack, heart procedure, or untreated severe coronary artery disease (within 3 months) - You have moderate to severe valve disease or complex congenital heart disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.


Locations(1)

University Medical Center Groningen

Groningen, Netherlands

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06514820


Related Trials