Evaluation of Risk of hEpatocellular Carcinoma

This study is identifying people at higher risk of developing liver cancer (hepatocellular carcinoma, or HCC) among those with fatty liver disease or other liver conditions, to allow earlier detection and prevention. **You may be eligible if...** - You are between 45 and 75 years old - You have been diagnosed with non-alcoholic fatty liver disease (NAFLD) or unexplained liver disease (with a moderate alcohol component acceptable) - You have significant liver scarring (F3–F4 fibrosis or cirrhosis), confirmed by biopsy or non-invasive tests - OR you have a family history of liver cancer in a first-degree relative, or carry certain genetic risk mutations - OR you are a male with type 2 diabetes or obesity AND carry at least 3 specific genetic risk variants - You are willing to sign informed consent **You may NOT be eligible if...** - You drink more than 60 g/day of alcohol (men) or 40 g/day (women) - You have chronic viral hepatitis (B or C) or autoimmune hepatitis - You have a known genetic liver disease (e.g., hemochromatosis, Wilson's disease) - You take medications known to cause liver disease - You have already been diagnosed with liver cancer - You have another serious condition with a life expectancy of less than 2 years Talk to your doctor to see if this trial is right for you.