RecruitingPhase 2NCT06570473

Feasibility Trial for a Right Ventricular Failure Platform Trial

Feasibility Trial for the Canadian Right Ventricular AdaptiVE (CRAVE) Platform for Therapies Targeting Right Ventricular Failure


Sponsor

University of Alberta

Enrollment

30 participants

Start Date

Jul 15, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The primary objective of the CRAVE feasibility trial is to assess the feasibility of conducting a larger CRAVE platform trial by performing a randomized trial of 30 participants with pulmonary hypertension and right ventricular dysfunction, comparing empagliflozin or ranolazine plus standard of care to standard of care alone.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This feasibility study looks at whether a standardized clinical trial platform can be built to test new treatments for right ventricular failure (RVF) — a serious condition where the right side of the heart becomes too weak to pump blood efficiently to the lungs. It tests whether patients with RVF can be enrolled in trials and tracked safely. **You may be eligible if:** - You are 18 or older with a history of right heart dysfunction or failure caused by pulmonary arterial hypertension, left heart disease, lung disease, or chronic blood clots in the lungs - You have symptoms affecting your daily life (NYHA class II-IV, meaning mild to severe functional limitation) - You have evidence of right heart dysfunction on recent blood tests and echocardiogram (within 3 months) **You may NOT be eligible if:** - You are unable to provide informed consent - You cannot comply with study procedures - You are in a clinical situation that makes participation unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGEmpagliflozin

Tablet

DRUGRanolazine

Tablet


Locations(5)

University of Calgary

Calgary, Alberta, Canada

University of Alberta

Edmonton, Alberta, Canada

The University of British Columbia

Vancouver, British Columbia, Canada

London Health Sciences Centre - University Hospital

London, Ontario, Canada

The Ottawa Hospital

Ottawa, Ontario, Canada

View Full Details on ClinicalTrials.gov

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NCT06570473


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