RecruitingNCT06572215
DYNAMic Renal Assessment: NOvel Methods to Assess KIDNEY Functional Reserve
Sponsor
King's College Hospital NHS Trust
Enrollment
44 participants
Start Date
Dec 14, 2023
Study Type
OBSERVATIONAL
Conditions
Summary
This is a feasibility study to assess new, more practical ways of measuring renal reserve.
Eligibility
Min Age: 40 Years
Inclusion Criteria1
- Patients with sickle cell nephropathy, diagnosed clinically or histologically. Sickle Cell patients will be confirmed Hb SS and eGFR (CKD-EPI) ≥ 135 ml/min/1.73m2 OR Previous living kidney donation Age ≥ 4No contraindication or known allergy to any trial medications. Willing and able to provide written informed consent
Exclusion Criteria1
- Aged \< 40 Unable or unwilling to provide informed consent Breastfeeding or pregnant women Patients involved in other interventional research studies.
Interventions
DRUGDapagliflozin
On Day 3 to 16, participants will take 10mg dapaglifozin (SGLT-2 inhibitor) orally once daily.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06572215
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