PRospective Observation on CErebral microvaScular Structure and Function
PRospective Observation on CErebral microvaScular Structure and Function (PROCESS): a Population-based Prospective Cohort Study
Beijing Tiantan Hospital
3,500 participants
Oct 18, 2024
OBSERVATIONAL
Conditions
Summary
This is a population-based prospective cohort study, aiming to assess the prevalence, distributional characteristics, and dynamic change of cerebral small vessel dysfunction in a Chinese community population using advanced vascular imaging techniques; meanwhile to investigate the effect of vascular risk factors on cerebral small vessel dysfunction, cardiovascular and cerebrovascular diseases, cognitive dysfunction, and mortality.
Eligibility
Inclusion Criteria3
- Community-dwelling adults aged 50-75 years;
- Registered Beijing household residents or residents who can be followed up stably in their own communities for a long period;
- Subjects with written informed consents.
Exclusion Criteria4
- Residents with moderate to severe disabilities (MRS ≥3), mental illness, stroke, dementia, and other serious neurological disorders (e.g., encephalitis, Parkinson's disease, epilepsy, brain tumors, and rare genetic diseases of the nervous system);
- Life expectancy of ≤4 years due to serious diseases such as end-stage cancer;
- Contraindications to magnetic resonance imaging such as implanted devices (e.g., pacemakers, defibrillators, and others);
- Residents who are participating in other studies.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
No interventions will be performed.
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06579677