Concurrent TMS-fMRI

This study is using a combination of two brain imaging technologies — transcranial magnetic stimulation (TMS, a non-invasive brain stimulation tool) and functional MRI — at the same time to better understand how the brain responds to stimulation in people with major depressive disorder (MDD). The study also includes healthy volunteers for comparison. The goal is to learn more about the brain circuits involved in depression. **You may be eligible if...** - You are between 18 and 65 years old and speak English - You have been diagnosed with major depressive disorder (for patient group) - OR you have no history of psychiatric illness and have low scores on depression and anxiety questionnaires (for healthy volunteer group) - You are able to understand and consent to research participation **You may NOT be eligible if...** - You have epilepsy or a seizure disorder - You have metal implants in your head, skull, or face near the stimulation target - You have a pacemaker, defibrillator, or non-MRI-compatible implanted device - You have metal fragments in your body (bullets, shrapnel) - You are claustrophobic or have uncontrolled high blood pressure - You are pregnant - You take opiates, blood pressure medications, or medications that affect blood flow - You have a history of stroke, brain surgery, brain tumor, or significant traumatic brain injury - You are unwilling to abstain from illicit drugs or alcohol before scans Talk to your doctor to see if this trial is right for you.