RecruitingNCT06637657

Guided Optimisation of Long-term Disease rEduction in secoNdary Prevention of CVD

Guided Optimisation of Long-term Disease rEduction in secoNdary Prevention of CVD (GOLDEN). A Prospective Observational Study of Long-term Outcomes.


Sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Enrollment

5,586 participants

Start Date

Jul 9, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to evaluate the implementation of a 'first-time-right' pharmacological treatment strategy in patients hospitalized with coronary artery disease. The main question it aims to answer is: Does early (immediately post-event) initiation of a full set of guideline-based, individualized, preventive medication lead to reductions in cardiovascular events compared to current practice (incremental titration strategies)? Researchers will compare the 'first-time-right' strategy group to the current practice group to see if there are improvements in major adverse cardiac and cerebrovascular events (MACE) at 36 months. Participants will: * Receive either the 'first-time-right' strategy or current practice for secondary prevention. * Be monitored (data collection) through routine clinical visits at baseline, 8 weeks, 12, and additional telephone contacts at 24, and 36 months after discharge. * Complete online questionnaires at hospitalization, 8 weeks, 12, 24, and 36 months after discharge.


Eligibility

Min Age: 18 Years

Inclusion Criteria3

  • >18 years of age (no upper limit)
  • Coronary event, i.e. ACS or coronary revascularisation
  • Able to provide informed consent

Exclusion Criteria2

  • (short-term planned) pregnancy or breast feeding
  • Dialysis

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Interventions

OTHERNo intervention (observational study)

No intervention, only guideline implementation (observational study)


Locations(1)

Amsterdam UMC

Amsterdam, Netherlands

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NCT06637657


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