Postoperative Basal Bolus or Sliding Scale Insulin Regimen in DM2 and Its Effect on Surgical Site Infections.
Postoperative Glucose Control with a Basal Bolus Versus Sliding Scale Insulin Regimen and Its Effect on the Incidence of Surgical Site Infections in People with Type 2 Diabetes Mellitus.
Abraham Hulst, MD, PhD
1,008 participants
Jan 3, 2025
INTERVENTIONAL
Conditions
Summary
A multicentre, matched-pair, cluster randomised controlled superiority trial to investigate the effect of a proactive basal bolus insulin regimen compared to the reactive sliding scale insulin regimen, targeting a glucose level of 3.9-10.0 mmol/L, to reduce the number of surgical site infections within the first 30 days postoperatively in adult patients with diabetes mellitus type 2.
Eligibility
Inclusion Criteria6
- Patients aged 18 or older
- Diagnosed with type 2 diabetes mellitus
- Undergoing gastointestinal or vascular surgery
- Admitted to one of the participating surgical wards
- Expected duration of stay at least one overnight stay
- Willing and able to provide informed consent
Exclusion Criteria6
- Diagnosed with type 1 diabetes mellitus
- Female of child-bearing potential who is pregnant or breastfeeding.
- Undergoing complete pancreatectomy
- Undergoing bariatric surgery
- Patients using a continuous insulin pump at home
- Patients undergoing a necrotectomy/wound debridement from a pre-existent wound.
Interventions
Combination of long-acting and short-acting insulin in a proactive schedule for achieving better blood glucose values postoperatively
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06638567