RecruitingNot ApplicableNCT06641115

Integrated Treatment for Opioid Use Disorder and PTSD

Integrated Treatment for Co-Occurring Opioid Use Disorder and Posttraumatic Stress Disorder

Sponsor

Medical University of South Carolina

Enrollment

76 participants

Start Date

Mar 1, 2025

Study Type

INTERVENTIONAL

Conditions

Opioid-use Disorder Posttraumatic Stress Disorder (PTSD)

Summary

This study will test a therapy intervention, HOPE, for individuals with opioid use disorder and posttraumatic stress disorder. Interested individuals will need to be taking medications for opioid use disorder (e.g., suboxone, naltrexone, methadone). Interested participants will complete a 10-12 week therapy, and be asked to complete surveys.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria6

Any gender; any race or ethnicity; aged 18-70 years old.
English-speaking
Meet DSM-5 diagnostic criteria for OUD.
Meet DSM-5 diagnostic criteria for PTSD and have some memory of their index traumatic event.
Must be maintained on a stable dose of medication for OUD for at least 1 month.
Participants taking psychotropic medications will be required to be maintained on a stable dose for at least 1 month before study initiation.

Exclusion Criteria5

Participants presenting with psychiatric contraindications (e.g., unmanaged psychosis or mania, or bipolar) will be excluded and referred clinically.
Participants considered an immediate suicide risk, with current suicidal ideation and a plan of intent, or displaying other high-risk behaviors (i.e., MOUD refusal, risky fentanyl use, etc.), as determined by the PI and study team. These individuals will complete a safety plan and be referred for treatment.
Participants meeting DSM-5 criteria for a concurrent, non-opioid, substance use disorder and who report that the other substance is their primary substance of use. These participants will be referred clinically for treatment.
Participants enrolled in ongoing evidence-based psychotherapy for substance use disorders or PTSD outside of medications for OUD and standard psychotherapy groups in treatment programs.
Medical problems requiring immediate and intensive treatment, such as unstable or symptomatic end stage liver disease.

Interventions

BEHAVIORALHOPE Therapy

Helping Opioid Use and PTSD with Exposure (HOPE) therapy is an integrated 10-12 week treatment for opioid use disorder and trauma/posttraumatic stress disorder