Regime for Vitamin D Maintenance in Post-Operative Patients
Regime for Vitamin D Maintenance in Post-Operative Patients (D-ECISIVE) Randomized Controlled Trial
Sengkang General Hospital
100 participants
Jan 1, 2026
INTERVENTIONAL
Conditions
Summary
Vitamin D plays a significant part calcium and phosphate haemostasis, thus, intrinsically critical for bone health. Increasing evidence also reveal that insufficient serum vitamin D levels also result in poor muscle health with such individuals having a compromised muscle building potential (4 times slower muscle building). Muscle health is a critical component of a post-surgical patient recovery, with impaired muscle function leading to reduced functional ability, resulting in a poorer quality of life. Poor muscle health also has negative repercussion on survivability, with reduced overall, and disease-specific survival, especially shown in cancer patients. Thus, maintenance of vitamin D levels post-surgery may be more critical than previously thought.
Eligibility
Inclusion Criteria5
- Serum 25-hydroxyvitamin D levels between 30-50ng/ml at 4-6 weeks after operation
- aged 21-65 years
- ability to provide informed consent
- accepts to take vitamin D supplements post-operatively and
- have their serum vitamin D levels checked periodically.
Exclusion Criteria7
- They have undergone minor procedures (Table code <4a)
- have a history of chronic kidney disease/end staged renal failure
- have previous history of ureteric/kidney stones
- known hyperparathyroidism
- are non-ambulatory independently
- have had known allergies to the commercially available high dose vitamin D formulations.
- Vulnerable personnel would be excluded from the study
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
High dose oral vitamin D supplementation (50,000 IU/once per month)
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06708741