RecruitingPhase 3NCT06708741

Regime for Vitamin D Maintenance in Post-Operative Patients

Regime for Vitamin D Maintenance in Post-Operative Patients (D-ECISIVE) Randomized Controlled Trial


Sponsor

Sengkang General Hospital

Enrollment

100 participants

Start Date

Jan 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

Vitamin D plays a significant part calcium and phosphate haemostasis, thus, intrinsically critical for bone health. Increasing evidence also reveal that insufficient serum vitamin D levels also result in poor muscle health with such individuals having a compromised muscle building potential (4 times slower muscle building). Muscle health is a critical component of a post-surgical patient recovery, with impaired muscle function leading to reduced functional ability, resulting in a poorer quality of life. Poor muscle health also has negative repercussion on survivability, with reduced overall, and disease-specific survival, especially shown in cancer patients. Thus, maintenance of vitamin D levels post-surgery may be more critical than previously thought.


Eligibility

Min Age: 21 YearsMax Age: 65 Years

Inclusion Criteria5

  • Serum 25-hydroxyvitamin D levels between 30-50ng/ml at 4-6 weeks after operation
  • aged 21-65 years
  • ability to provide informed consent
  • accepts to take vitamin D supplements post-operatively and
  • have their serum vitamin D levels checked periodically.

Exclusion Criteria7

  • They have undergone minor procedures (Table code <4a)
  • have a history of chronic kidney disease/end staged renal failure
  • have previous history of ureteric/kidney stones
  • known hyperparathyroidism
  • are non-ambulatory independently
  • have had known allergies to the commercially available high dose vitamin D formulations.
  • Vulnerable personnel would be excluded from the study

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Interventions

DRUGVitamin D

High dose oral vitamin D supplementation (50,000 IU/once per month)


Locations(1)

Sengkang General Hospital

Singapore, Singapore, Singapore

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NCT06708741


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