RecruitingNot ApplicableNCT07561138

Nutrition and Exercise Prehabilitation in Patients Awaiting Liver Transplantation

Evaluation of Protein Distribution Optimization With Exercise Regimen on Nutritional Status, Body Composition and Functional Status in Patients Awaiting Liver Transplantation: The POWER-LT Randomized Clinical Trial

Sponsor

Kalliopi Anna Poulia

Enrollment

90 participants

Start Date

Jan 8, 2026

Study Type

INTERVENTIONAL

Conditions

Sarcopenia Liver Cirrhosis Frailty Malnutrition Liver Transplantation End Stage Liver Disease

Summary

This study aims to evaluate the effects of a diet with even protein distribution plus exercise (Group A) versus a diet with skewed protein distribution plus exercise (Group B) versus standard dietary and physical activity advice (Group C) on nutritional status, body composition and functional status in patients awaiting liver transplantation.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a behavioral approach called Diet with even protein distribution plus exercise program, a behavioral approach called Diet with skewed protein distribution plus exercise program, and others for people with end stage liver disease, frailty, and other related conditions. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 18 Years to 70 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALDiet with even protein distribution plus exercise program

Diet of 1.2-1.5 g protein/kg dry body weight/day, equally divided (33.3% at 3 main meals) \| Exercise program: 3 days/week aerobic and 2 days/week resistance \| Duration: 12 weeks

BEHAVIORALDiet with skewed protein distribution plus exercise program

Diet of 1.2-1.5 g protein/kg dry body weight/day, unequally divided (10.0% at breakfast, 60.0% at lunch, 30.0% at dinner) \| Exercise program: 3 days/week aerobic and 2 days/week resistance \| Duration: 12 weeks

BEHAVIORALStandard dietary and physical activity advice

Standard dietary and physical activity advice \| Duration: 12 weeks