New Mechanisms of Obesity
Pathogenic Mechanisms of Obesity and Its Cardiometabolic Complications
Yale University
55 participants
Nov 13, 2025
INTERVENTIONAL
Conditions
Summary
Given the pervasiveness of Pediatric Obesity, it is imperative to understand its pathophysiology and develop alternative strategies to reverse this condition. Herein, investigators propose to elucidate the interaction between colonic fermentation and insulin resistance in modulating metabolism in youth with obesity.
Eligibility
Inclusion Criteria3
- Age 15 to 22 years
- In puberty (girls and boys: Tanner stage III-V);
- BMI \>85th
Exclusion Criteria5
- Pregnancy;
- endocrinopathies (e.g., Cushing syndrome);
- substance abuse;
- medications affecting insulin resistance such as metformin, GLP-1 analogues; -
- high fibers intake (\> 30g/day) as assessed by a 3-day food record.
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Interventions
Each arm will undergo a study to induce colonic fermentation through lactulose at the beginning and at the end of the 12 weeks.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06768827