RecruitingNot ApplicableNCT06769828

Ga-68-FAPI-46 PET for CRC Recurrence Detection in Elevated CEA

Diagnostic Performances of Ga-68-FAPI-46 PET in CRC Patients with Rising Serum CEA During the Post-treatment Surveillance

Sponsor

Koo Foundation Sun Yat-Sen Cancer Center

Enrollment

30 participants

Start Date

Feb 1, 2025

Study Type

INTERVENTIONAL

Conditions

Colorectal Cancer Recurrent

Summary

This single-center, phase II clinical trial investigates the diagnostic efficacy of Ga-68-FAPI-46 PET scans in detecting colorectal cancer (CRC) recurrence during post-treatment surveillance, particularly in patients with elevated serum carcinoembryonic antigen (CEA). The study compares the sensitivity, specificity, and accuracy of Ga-68-FAPI-46 PET with the conventional F-18-FDG PET scans, aiming to enhance recurrence detection in CRC patients who underwent curative surgery. Thirty participants will be enrolled and monitored through imaging studies and clinical follow-up.

Eligibility

Min Age: 20 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new type of PET scan (called Ga-68-FAPI-46) to detect colorectal cancer that has come back after surgery in patients whose blood CEA levels (a cancer marker) are elevated. Researchers want to see if this scan finds recurrent cancer more accurately than the standard FDG PET scan. **You may be eligible if...** - You are 20 or older and had colorectal cancer surgery aimed at a cure - Your CEA blood level is above the normal range - You have already had or are scheduled for a standard FDG PET scan - You can lie flat for at least 30 minutes - You are willing to sign informed consent **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have severe kidney problems - You have a known allergy to radioactive imaging agents - You have been diagnosed with another type of cancer - You are unable to undergo PET scanning Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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