RecruitingNCT06785506

Multiple-biomarker Approach for Individualized Treatment of Heart Failure with Preserved Ejection Fraction

A Dynamic, Multiple-biomarker Approach Aiming for Individualized Treatment of Heart Failure with Preserved Ejection Fraction (ADAPT-HFpEF)

Sponsor

Erasmus Medical Center

Enrollment

200 participants

Start Date

Nov 25, 2022

Study Type

OBSERVATIONAL

Conditions

Chronic Heart Failure Heart Failure With Preserved Ejection Fraction Heart Failure, Diastolic

Summary

The primary objective is to investigate the association between temporal evolutions of blood biomarkers and clinical adverse events, in order to produce a dynamic, individual, and accurate prediction model for patients with HFpEF. Moreover several secondary objectives will be investigated.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Age of 18 years or older
Capable of understanding and signing informed consent
A diagnosis of HFpEF according to the HFA-PEFF diagnostic algorithm of the ESC or/and a high (90%) probability of HFpEF according to the H2FPEF score, i.e. a score of 6 or higher.

Exclusion Criteria10

History of LVEF ≤40%
Scheduled for surgery or intervention for both coronary and non-coronary indication within 6 months of inclusion
Impaired renal function, defined as eGFR \< 20 mL/min/1.73 m2 (CKD-EPI) or requiring dialysis at the time of screening
Acute or chronic liver disease, defined by serum levels of transaminases or alkaline phosphatase more than three times the upper limit of normal at screening
COPD Gold stage IV
Congenital heart disease
Pregnancy
Coexistent condition with life expectancy of \<1 year
Unlikely to appear at all scheduled follow-up visits
Linguistic barrier