RecruitingNot ApplicableNCT06789809

Exercise Physiology in Patients With Aortic Aneurysm and Its Correlation With Mechanical Properties of Aortic Tissue

Sponsor

The Cleveland Clinic

Enrollment

35 participants

Start Date

Nov 23, 2023

Study Type

INTERVENTIONAL

Conditions

Aortic Aneurysm

Summary

Aortic aneurysm patients benefit from exercise yet patients and physicians do not know a safe level. Cardiac MRI (CMR) is the most comprehensive imaging modality for phenotypic evaluation of patients with cardiac disease but it has not been used to study aneurysm patients. The purpose of this project is use exercise CMR to understand regional aortic function and quantify aortic elasticity in these populations while exercising. This project will correlate the exercise CMR data with the biomechanical properties of the patient's aortic tissue, including epiaortic ultrasound and TEE performed during aortic repair, and explanted aortic specimens subjected to ex vivo uniaxial tensile testing. Correlating this data with aortic response to exercise will allow us to understand how aortic size, in vivo circumferential strain values, ex vivo aortic efficiency and mechanical failure all relate to exercise physiology.

Eligibility

Min Age: 18 Years

Inclusion Criteria9

Healthy controls for baseline comparison
Must be 18 years or older
No history of cardiovascular disease, neither hypertension, diabetes nor hypercholesterolemia
Aneurysm patients who have not yet been operated on but are currently being monitored
Must be 18 years or older
No history of operation for aortic aneurysm
Pre-operative aneurysm patients: imaged pre-operatively and 12 months
Patients admitted at the CCF cardiothoracic services for elective surgery due to aortic aneurysms
Must be 18 years or older

Exclusion Criteria21

For all patients:
Contra-indication for MRI
Heart pacemaker/defibrillator.
Electronic/implanted stimulators or devices, including deep brain stimulator, vagus nerve stimulator, bladder stimulator, spine stimulator, neurostimulators; implanted electrodes or wires.
Cochlear implant or other ear implants.
Implanted drug pumps (insulin, narcotic/pain medications, drugs to treat spasticity).
Programmable shunt.
Aneurysm clips and coils.
Stents (not located in heart).
Filters (for example, blood clot filters).
Metal fragment in your body or eye (eg, BBs, bullets, shrapnel, metal pieces or shavings).
Congenital heart diseases such as patent ductus arteriosus, coarctation of aorta, ASD and VSD
Presence of A-V fistula or intracardiac shunts
Moderate or severe dysfunction in multiple valves
Patients with significant claustrophobia
Patients unable to pedal a supine bicycle
Those who require supplemental oxygen
Healthy controls for baseline comparison
Excluded if using cardioprotective medication
Have a bicuspid aortic valve diagnosed using MRI
Pre-operative aneurysm patients: imaged pre-operatively and at 12 months a. Patients with traumatic aortic rupture