A Study of Sotorasib in People With Brain Tumors

This study is examining how well sotorasib — a targeted therapy that blocks a mutation called KRAS G12C — penetrates into brain tumors in patients who are already scheduled for brain surgery, helping researchers understand if this drug can effectively treat brain tumors or brain metastases with this mutation. **You may be eligible if...** - You are 18 or older - You have one or more brain tumors (either primary or metastatic) that need to be removed or biopsied by a neurosurgeon - Your general health is reasonably good (Karnofsky score of 60 or higher) - You have a life expectancy of more than 12 weeks - Your blood counts, kidney, liver, and clotting function are adequate **You may NOT be eligible if...** - You have a known allergy to sotorasib or its ingredients - Your prior cancer treatments have not been adequately washed out - You require ongoing blood transfusions or growth factor support to maintain blood counts Talk to your doctor to see if this trial is right for you.