RecruitingNCT05342454

A Comprehensive Clinical fMRI Software Solution to Enable Mapping of Critical Functional Networks and Cerebrovascular Reactivity in the Brain

Sponsor

M.D. Anderson Cancer Center

Enrollment

1,720 participants

Start Date

May 23, 2022

Study Type

OBSERVATIONAL

Conditions

Brain Tumor

Summary

Our preliminary work demonstrates that an integrated fMRI software solution, incorporating tb-fMRI, rs-fMRI, and CVR mapping, is clinically feasible and helps clinicians plan brain tumor resection. We have developed a novel automated seed selection method that can accurately map language networks from rs-fMRI. We hypothesize that our innovative approach to enhance, optimize, and validate our preliminary software and integrate it with an established fMRI platform will create robust solutions for clinical RSN and CVR mapping. Partnering with NordicNeuroLab (NNL) will leverage the professional software development by a seasoned commercial MRI software producer in coordination with leading clinical and research experts at MD Anderson. The research will be conducted through three specific aims: 1. Develop a clinical software platform for mapping RSNs and determine optimized workflow for presurgical localization of eloquent areas. 2. Develop a clinical software platform for mapping CVR and determine optimized workflow for identifying and visualizing brain areas with potential false-negative fMRI results. 3. Test and validate RSN and CVR mapping software in patients undergoing neurosurgery.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating a specialized brain mapping software that uses functional MRI (fMRI) to identify critical brain areas — like those controlling speech, movement, and memory — before brain tumor surgery, to help surgeons avoid damaging these areas. **You may be eligible if...** - You are 18 years or older - You are scheduled for brain tumor removal surgery - You will undergo pre-surgical fMRI as standard care - You are planned to have direct cortical stimulation (electrical brain mapping) during surgery - For the retrospective part: you had a pre-surgical fMRI at MD Anderson since May 2004 **You may NOT be eligible if...** - You cannot give informed consent - You cannot undergo an MRI - You are unable to cooperate with the required tasks during the fMRI Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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