Lidocaine and Dexmedetomidine Infusions for Intraoperative Bleeding in Functional Endoscopic Sinus Surgery
A Randomized Double-Blind Trial Comparing Lidocaine and Dexmedetomidine Infusions for Intraoperative Bleeding in Patients Undergoing Functional Endoscopic Sinus Surgery
Ain Shams University
40 participants
Mar 1, 2025
INTERVENTIONAL
Conditions
Summary
This work aims to compare lidocaine and dexmedetomidine infusions for intraoperative bleeding in patients undergoing functional endoscopic sinus surgery.
Eligibility
Inclusion Criteria3
- Age from 18 to 65 years old.
- American Society of Anesthesiologists (ASA) physical status I - II.
- Scheduled for elective functional endoscopic sinus surgery.
Exclusion Criteria15
- Diabetes mellitus.
- Coagulation disorders.
- Kidney and liver dysfunction.
- Cerebrovascular disease.
- Cardiovascular problems.
- High blood pressure.
- Asthma.
- Chronic obstructive pulmonary disease (COPD).
- End organ damage.
- Psychosis.
- Taking antipsychotic drugs.
- Allergy to study drugs.
- Substance abuse.
- Taking beta blockers.
- Heart rate of \< 55 beat/minute.
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Interventions
Patients will receive lidocaine (1.5 mg/kg loading then 1mg/kg/h infusion) just after induction of anesthesia induction and continued until the end of the operation.
Patients will receive 1 μg/kg dexmedetomidine infusion over 10 min as a loading dose then 0.4-0.7 μg/kg/h just after induction of anesthesia induction and continued until the end of the operation.
Locations(1)
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NCT06848764