Psilocybin With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring PTSD & Alcohol Use Disorder (AUD)

This study tests whether psilocybin (the active compound in "magic mushrooms"), combined with psychological support, can help military veterans and first responders who have both PTSD and alcohol use disorder reduce their drinking and PTSD symptoms. **You may be eligible if:** - You are a US military veteran or active first responder (EMT, paramedic, firefighter, or police officer) - You are between 21 and 65 years old - You meet diagnostic criteria for both PTSD and alcohol use disorder - You want to reduce or stop drinking - You have a trusted person who can stay with you overnight after the treatment session - You live near the University of Washington and can attend multiple in-person visits - You have access to the internet and a computer or smartphone **You may NOT be eligible if:** - You have a history of seizures, serious heart disease, stroke, or severe asthma - You have a history of schizophrenia, schizoaffective disorder, or bipolar disorder - You had a serious suicide attempt in the past 12 months - You currently take antidepressants, antipsychotics, or mood stabilizers - You are currently in CBT, EMDR, or other evidence-based PTSD therapy - You have a history of hallucinogen use disorder or have abused psychedelics - You are pregnant, breastfeeding, or planning to become pregnant - You are enrolled in another clinical trial Talk to your doctor to see if this trial is right for you.