Autistic Symptomatology and Sensory Profile in Children With Prader-Willi Syndrome
University Hospital, Toulouse
75 participants
Apr 7, 2025
OBSERVATIONAL
Conditions
Summary
Prader-Willi Syndrome (PWS) is a rare neurodevelopmental disorder stemming from genetic damage in the 15q11-q13 region, leading to hypothalamic dysfunction. Individuals with PWS often exhibit social interaction challenges, intellectual deficits, significant eating disorders, mood disturbances, and sensory-related autistic features. Although PWS is recognized by DSM-5 as a genetic cause of Autism Spectrum Disorder (ASD), ASD diagnosis in PWS remains rare in France. The CASSPER study aims to investigate the distinct autistic and sensory profiles in children with PWS, also analyzing the potential impact of early oxytocin treatment on these manifestations, in line with recommendations for early and tailored intervention.
Eligibility
Inclusion Criteria4
- Child with genetically confirmed PWS and identification of genetic subtype;
- Child aged between 3 and 16 years;
- Hospitalisation or multidisciplinary consultation planned for the child's routine follow-up at one of the investigating centres;
- No parental/legal guardian objection.
Exclusion Criteria3
- Change in psychotropic treatment (start, change in dose or discontinuation) in the past 3 months;
- Inability to provide clear information to parents/legal guardian;
- Not covered by social security.
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Interventions
children receive questionnaires and sensorial test
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06877715