Study of Oral Fluid Testing Approach
Oral Fluid Testing to Assess Cannabis Non-Use in Remote Clinical Trials
Boston Children's Hospital
200 participants
Oct 27, 2025
OBSERVATIONAL
Conditions
Summary
The purpose of this study is to identify and evaluate oral fluid testing as a biologic measure of cannabis use days that can be assessed remotely. The researchers will conduct this fully virtual study among a community sample of 200 individuals aged 18-30 years who have used cannabis at least 1 time per week on average in the past 30 days. Participants will complete oral fluid (saliva) tests, urine tests, and Timeline Follow-back interviews (self-report) that indicate their recent cannabis use (delta-9-THC). Participants will present for 3 virtual study visits across \~3-4 weeks and be asked to complete activities in between: Study Visit 1 (Day 0; informed consent, baseline survey, TLFB interview), Study Visit 2 (\~Day 7; TLFB interview, urine testing), 6 days of at-home videorecorded oral fluid testing, Study Visit 3 (\~Day 21; TLFB interview, urine test, oral fluid test, survey, interview).
Eligibility
Inclusion Criteria6
- Age 18 to 30 years
- Cannabis use on \>=1x/week in the past 30 days
- Ownership of a portable device that is capable of videoconference and videorecording (i.e., smartphone, tablet computer, or laptop computer)
- Ability to read and speak English
- Availability for duration of the study (3-4 weeks).
- To proceed to oral fluid testing, positive result for urinary TCH-COOH
Exclusion Criteria1
- • Inability/unwillingness to provide contact information
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Interventions
Participants will be asked to complete at-home urine test(s) and a series of oral fluid tests.
Locations(1)
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NCT06891235