TACE Combined Surgery for the Resectable Huge HCC

This study is comparing two surgical strategies for large liver cancers (hepatocellular carcinoma, or HCC) greater than 10 cm in size: surgery alone versus surgery preceded by a procedure called TACE (transarterial chemoembolization), which delivers chemotherapy directly to the tumor through the blood vessels to shrink it first. The goal is to find out whether pre-treating large liver tumors with TACE before surgery improves survival and reduces the chance of recurrence. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with primary liver cancer (HCC) with a tumor larger than 10 cm - Your cancer has not spread to blood vessels or outside the liver - You are healthy enough for liver surgery, with adequate remaining liver function - Your performance status and blood tests meet the study requirements **You may NOT be eligible if...** - Your cancer has spread into major blood vessels or to other organs - Your tumor is smaller than 10 cm - You have previously had liver cancer (recurrent HCC) - You have serious heart problems or other major medical conditions - You have significant portal hypertension (high blood pressure in the liver's blood vessels) with complications Talk to your doctor to see if this trial is right for you.